Homologous recombination counteracts mismatch repair to promote fertility and genetic diversity

The DNA mismatch repair (MMR) system is classically viewed as being anti-recombinogenic during meiosis because it mediates heteroduplex rejection to inhibit homeologous recombination, leading to postzygotic isolation between closely related species. In this forum article, conversely, we summarize a very recent study showing that homologous recombination (HR) proteins can antagonize MMR.