Genetic architecture and analysis practices of circulating metabolites in the NHLBI Trans-Omics for Precision Medicine Program

We cataloged 1,729 circulating metabolites from two metabolomics core laboratories among eight studies. We provided recommendations for TOPMed metabolite data harmonization and processing. We also provided pooled and sex-stratified metabolite-genetic summary results, revealing the genetic architecture of circulating metabolites and offering insights into metabolic regulation.