Mendelian randomization linking metabolites with enzymes reveals pathway regulation and therapeutic avenues

Mendelian randomization (MR) is widely used to identify causality between human traits; however, it suffers from high error rates. Van der Graaf et al. benchmark MR using human metabolic networks to understand MR’s failure modes. Extensive biological follow-up reveals that up to 43% of MR positives have plausible literature support.