Large-scale integration of omics and electronic health records to identify potential risk protein biomarkers and therapeutic drugs for cancer prevention

This study established an analytical framework that integrates large-scale cancer GWASs, proteomic data, and EHRs to identify druggable risk proteins and potential therapeutic candidates for cancer prevention. The authors reported 36 potentially druggable proteins and demonstrated that several approved drugs (e.g., acetazolamide) may confer preventive effects against colorectal cancer.