Genetic regulation of the plasma proteome and its link to cardiometabolic disease in Greenlandic Inuit

We conducted a protein quantitative trait locus (pQTL) study in 3,707 Greenlanders, identifying 251 associations, including 70 novel signals. We compared variance explained with Europeans from the UK Biobank, linked pQTLs to cardiovascular outcomes, and uncovered protein associations with Arctic-enriched variants, underscoring the importance of pQTL studies in diverse populations.