Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits

To investigate the underlying mechanisms of complex traits, we performed an eQTL meta-analysis in skeletal muscle and identified 18,818 conditionally distinct signals for 12,283 genes. Colocalization with GWASs nominated 1,342 genes with potential disease relevance, and integration across eQTL tissues nominated genes for 36% of type 2 diabetes GWAS signals.