Local ancestry-informed GWAS of warfarin dose requirement in African Americans identifies a CYP2C19 splicing QTL

Singh et al. revealed and replicated an association between rs7906871 and stable warfarin dose in an African American population found through the addition of local ancestry inference. The variant was further associated with splicing changes within CYP2C19, which metabolizes 10%–15% of drugs currently prescribed, indicating broader implications for this finding.