A scalable framework for identifying allelic series from summary statistics

COAST-SS extends the coding-variant allelic series test to operate on summary statistics: per-variant effect sizes, standard errors, and local linkage disequilibrium (LD). COAST-SS controls the type I error, is robust to LD misspecification, and enables rapid genome-wide scans. We apply COAST-SS to identify lipid-trait allelic series in a meta-analyzed cohort of 840,000.